Kim, Young-Bum, Odile Peroni, William Aschenbach, Yasuhiko Minokoshi, Ko Kotani, Ariel Zisman, Ronald Kahn, Laurie Goodyear, and Barbara Kahn. 2005. “Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism”. Mol Cell Biol 25 (21): 9713-23.
Abstract
Mice with muscle-specific knockout of the Glut4 glucose transporter (muscle-G4KO) are insulin resistant and mildly diabetic. Here we show that despite markedly reduced glucose transport in muscle, muscle glycogen content in the fasted state is increased. We sought to determine the mechanism(s). Basal glycogen synthase activity is increased by 34% and glycogen phosphorylase activity is decreased by 17% (P
Last updated on 03/08/2023