Blackwell, T.Keith. 2004. “Germ Cells: Finding Programs of Mass Repression”. Current Biology 14 (6): R229-R230.
Abstract
Transcription is globally silenced in the germline of animals. Recent studies have shown that, in Caenorhabditis elegans, this silencing is initially mediated through direct repression, but in Drosophila, the factors involved include pgc, a non-coding cytoplasmic RNA. Why are these mechanisms so diverse and complex?